Pre-implantation genetic diagnosis » Who should have PGD?

Who should have PGD?

  • Women with advanced Maternal Age


    Women with advanced maternal age have a higher likelihood of producing embryos with chromosomal abnormalities, a condition also known as aneuploidy. The occurrence of aneuploidy usually increases with age.

 

Aneuploidy rate in patients of different age groups undergoing IVF

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                                                  Maternal Age

 Lee et al. (2006) Reproductive BioMedicine Online, 12(Suppl 1):36

  • Patients with Inherited Genetic Diseases


    Genetic diseases such as Alpha Thalassaemia are hereditary. For example, parents who are both carriers of the disease have a 25% chance of having a child with hydrops fetalis a condition which causes death of the baby before or shortly after birth. PGD can help to eliminate the risk of conceiving a baby with Thalassaemia.

  • Couples Who Have Experienced Recurrent Miscarriages and Recurrent IVF Failures


    Abnormal embryos have impaired developmental potential and will usually fail to implant. Even if they do implant, the majority of these abnormal conceptions will result in miscarriages. This could be the underlying cause of multiple miscarriages or infertility for couples who tried many IVF cycles without success. Using PGD to eliminate abnormal embryos and to select only normal embryos for implantation may improve the chances of a successful pregnancy (Munne et al., 2005, Platteau et al., 2006).

  • Couples Who Can Possibly Pass on Sex-linked Diseases to Their Child


    Sex-linked diseases are diseases caused by mutations that occur at the sex chromosomes (Chromosome X and Y). For example, hemophilia is an inherited blood disease which only affects the male off-spring. Therefore, selecting female embryos for transfer can avoid the problem.