In the slew of emerging technologies within assisted reproductive techniques (ART), ZyMot has stood out as a groundbreaker, especially for IVF and ICSI applications. This simple yet effective sperm selection device has been a ray of hope to males struggling with infertility and low concentration of motile sperm.
What is ZyMot?
ZyMot is a microfluidic sperm selection device enabling the isolation of the healthiest, most motile sperm for implantation. A stark contrast to traditional sperm preparation methods, ZyMot segregates sperms based on :
- DNA Integrity: Sperms with lower levels of DNA fragmentation are given preference since it’s a critical factor for successful fertilization and embryo development.
- Motility and Morphology: Isolates the strongest and best-formed sperm based on energetic movement and component shapes.
How It Works
This device uses the mechanics of microfluidics to separate the healthy sperms from any of those with developmental or morphological defects. The healthy sperms swim normally and are able to clear the membrane filter while the rest are left behind in the media.
Here’s a step-by-step process of how we, at TMC Fertility, use ZyMot in our IVF applications :
- Sperms are prepared by first washing in bicarbonate-buffered media or HEPES media.
- A drop of the solution is placed into the “inlet” area on the ZyMot testing kit.
- The kit is then placed into a chamber with environments suited to the media used and incubated at body temperature (36°C – 37°C) for 30 minutes.
- The healthy sperms are extracted from the outlet well on the kit for use with IVF treatment procedures.
Who Benefits from ZyMot?
ZyMot may be especially helpful for couples who find themselves in the following scenarios:
- Male Factor Infertility: Various male-centric deficiencies including low sperm count and motility, morphologically-deviant sperm, or significant DNA fragmentation
- Recurrent IVF Failures: Couples who have gone through multiple treatment cycles with no avail could benefit from the use of ZyMot.
- Unexplained Infertility: In cases where there is no clear diagnosis, this device can serve as an enhancer to aid the success rate of the treatment cycle.
Why Choose ZyMot?
Besides being effective, your fertility specialist also uses ZyMot is for the following reasons :
- Non-Invasive: ZyMot uses microfluidics to delicately separate sperms from the ejaculate without chemicals or forceful centrifugation.
- Enhanced Outcomes: Studies on its use reveal better results with fertilization rates, embryo quality, and even live birth rates.
- Quick and Easy: The procedure integrates seamlessly into existing IVF protocols.
Conclusion
ZyMot is a promising avenue for couples struggling with their infertility – especially with the male factor. Additionally, it also works as a success rate enhancer in cases with an unclear diagnosis. Consult with your fertility specialist to see if it’s right for your treatment plan.